HP相关良性胃病患者血清胃泌素及胃动素检测及意义.docVIP

HP相关良性胃病患者血清胃泌素及胃动素检测及意义 　 作者：何守搞，王超，潘小炎，黄赞松，周喜汉，尹毅霞 【摘要】 目的 探讨血清胃泌素和胃动素的释放与幽门螺杆菌（HP）相关性胃炎及消化性溃疡的关系。方法 采用放射免疫计数仪对268例HP阳性、183例HP阴性及150例HP清除后良性胃病患者血中的胃动素和胃泌素水平进行检测。结果 HP阳性的慢性浅表性胃炎（CSG）、胃溃疡（GU）、十二指肠球部溃疡（DU）患者的血清胃泌素和胃动素水平：DU gt;GU gt; CSG(Plt;0.01)。HP阳性患者血清胃泌素水平较HP阴性患者高(Plt;0.05或0.01)，而胃动素水平恰好相反(Plt;0.01)。HP清除后病人血清胃动素水平升高、胃泌素水平下降(Plt;0.01)。结论 HP感染可引起血清胃泌素水平升高、胃动素水平降低。 【关键词】 螺杆菌，幽门；胃炎；胃溃疡；十二指肠溃疡；胃泌素类；促胃动素 　　Abstract: Objective To investigate the relationship between the secretion of serum gastrin and motilin and Helicobacter pylori (Hp)-associated chronic gastritis and peptic ulcer. Methods 601 patients with benign gastric disease, including 268 cases with Hp positive (of 150 patients with Hp eradication) and 183 with Hp negative were involved in this study. Serum gastrin and motilin were measured by using radioimmunoassay. Results The levels of serum gastrin and motilin in Hp positive patients with chronic superficial gastritis (CSG), gastric ulcer (GU) and duodenal ulcer (DU) were different. DU ranged the highest, next was GU, and CSG was the lowest, there was statistical significant difference (Plt;0.01). The levels of serum gastrin in Hp positive patients was higher than that in Hp negative patients (Plt;0.05 or 0.01), and the levels of serum motilin were contrary to that (Plt;0.01). The levels of serum motilin in patients after Hp eradication were higher than before eradication, and the levels of gastrin decreased (Plt;0.01). Conclusion Hp infection may induce more serum gastrin secretion and down-regulate motilin. 　　Key words: Helicobacter pylori; gastritis; stomach ulcer; duodenal ulcer; gastrins; motilin 　　幽门螺杆菌(HP)与慢性胃炎及消化性溃疡的关系已经得到了普遍认可，而胃肠激素，特别是胃泌素和胃动素在消化道疾病中的关系亦一直受到人们的关注。为探讨血清胃泌素和胃动素的释放与HP相关性胃炎及消化性溃疡的关系，笔者对HP阳性和HP阴性两组良性胃病患者血中的胃动素和胃泌素进行检测，报告如下： 　　1 资料与方法 　　1.1 病例选择 所有的患者均来自2005年1月～2006年7月的消化内科门诊和住院病例，均有不同程度的腹痛、腹胀、恶心、早饱等症状，经胃镜检查和必要的组织活检后确诊为良性胃病，HP阳性患者268例，其中男152例，女116例；包括慢性浅表性胃炎（CSG）150例，十二指肠球部溃疡（DU）80例，胃溃疡（GU）38例；10岁～18例，20岁～50例，30岁～82例，40岁～54例，50岁～50例，6