detection of flt3 oncogene mutations in acute myeloid leukemia using conformation sensitive gel electrophoresisflt3致癌基因突变的检测在急性髓系白血病使用构象敏感凝胶电泳.pdfVIP
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detection of flt3 oncogene mutations in acute myeloid leukemia using conformation sensitive gel electrophoresisflt3致癌基因突变的检测在急性髓系白血病使用构象敏感凝胶电泳
Int. J. Mol. Sci. 2008, 9, 2194-2204; DOI: 10.3390/ijms9112194 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms/ Article Detection of FLT3 Oncogene Mutations in Acute Myeloid Leukemia Using Conformation Sensitive Gel Electrophoresis Mamdooh Gari 1,*, Adel Abuzenadah 1, Adeel Chaudhary 1, Mohammed Al-Qahtani 1, Huda 1 1 2 3 2 Banni , Waseem Ahmad , Fatin Al-Sayes , Sahira Lary and Ghazi Damanhouri 1 Medical Technology Department, Faculty of Applied Medical Sciences, Genomic Medicine Unit, Center of Excellence of Genomic Research. P. O. Box 80216, King Abdulaziz University-Jeddah, Kingdom of Saudi Arabia. E-Mails: aabuzenadah@.sa (A. A.); adeel.gc@ (A. C.); mhalqahtani@.sa (M. A.); hbanni@.sa (H. B.) 2 Hematology Department, Faculty of Medicine, King Abdulaziz University- Jeddah, Kingdom of Saudi Arabia. E-Mails: fatinsayes@ (F. A.); ghazid@ (G. D.) 3 Biochemistry Department, Faculty of Sciences, King Abdulaziz University- Jeddah, Kingdom of Saudi Arabia. E-Mail: slary@.sa (S. L.) * Author to whom correspondence should be addressed; E-Mail: mgari@.sa; Tel. +966 2 6400000 ext 25217; Fax: +966 2 6952521 Received: 13 June; in revised form: 27 October 2008 / Accepted: 4 November 2008 / Published: 11 November 2008 Abstract: FLT3 (fms-related tyrosine kinase 3) is a receptor tyrosine kinase class III that is
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