detection of cardiac biomarkers using single polyaniline nanowire-based conductometric biosensors心脏生物标志物的检测使用单聚苯胺nanowire-based电导传感器.pdfVIP

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detection of cardiac biomarkers using single polyaniline nanowire-based conductometric biosensors心脏生物标志物的检测使用单聚苯胺nanowire-based电导传感器.pdf

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detection of cardiac biomarkers using single polyaniline nanowire-based conductometric biosensors心脏生物标志物的检测使用单聚苯胺nanowire-based电导传感器

Biosensors 2012, 2, 205-220; doi:10.3390/bios2020205 OPEN ACCESS biosensors ISSN 2079-6374 /journal/biosensors/ Article Detection of Cardiac Biomarkers Using Single Polyaniline Nanowire-Based Conductometric Biosensors Innam Lee 1, Xiliang Luo 2, Jiyong Huang 1, Xinyan Tracy Cui 2 and Minhee Yun 1,* 1 Department of Electrical and Computer Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA; E-Mails: inl8@ (I.L.); jih44@ (J.H.) 2 Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA; E-Mails: xiliangluo@ (X.L.); xic11@ (X.T.C.) * Author to whom correspondence should be addressed; E-Mail: miy16@ ; Tel.: +1-412-648-8989; Fax: +1-412-624-8003. Received: 20 March 2012; in revised form: 20 April 2012 / Accepted: 25 April 2012 / Published: 14 May 2012 Abstract: The detection of myoglobin (Myo), cardiac troponin I (cTnI), creatine kinase-MB (CK-MB), and b-type natriuretic peptide (BNP) plays a vital role in diagnosing cardiovascular diseases. Here we present single site-specific polyaniline (PANI) nanowire biosensors that can detect cardiac biomarkers such as Myo, cTnI, CK-MB, and BNP with ultra-high sensitivity and good specificity. Using single PANI nanowire-based biosensors integrated with microfluidic channels, very low concentrations of Myo (100 pg/mL), cTnI (250 fg/mL), CK-MB (150 fg/mL), and BNP (50 fg/mL) were detected. The single PANI nanowire-based biosensors displayed linear sensing profiles for concentrations ranging from hundreds (fg/mL) to