有哪些信誉好的足球投注网站detection and early phase assessment of radiation-induced lung injury in mice using micro-ct检测和早期阶段的评估辐射诱导肺损伤小鼠使用ct机.pdfVIP
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detection and early phase assessment of radiation-induced lung injury in mice using micro-ct检测和早期阶段的评估辐射诱导肺损伤小鼠使用ct机
Detection and Early Phase Assessment of Radiation- Induced Lung Injury in Mice Using Micro-CT Shigeyoshi Saito*, Kenya Murase Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, Osaka, Japan Abstract Radiation therapy is an important therapeutic modality for thoracic malignancies. However, radiation-induced pulmonary injuries such as radiation pneumonitis and fibrosis are major dose-limiting factors. Previous research shows that micro- computed tomography (micro-CT) can detect radiation-induced lung injuries a few months following irradiation, but studies to assess the early response of lung tissue are lacking. The aim of this study was to determine if micro-CT could be used to detect and assess early-phase radiation–induced lung injury in mice. Twenty-one animals were divided into three groups: normal (n = 7), one day after x-ray exposure (n = 7), and at four days after x-ray exposure (n = 7). The x-ray-exposed groups received a single dose of 20 Gy, to the whole lung. Histology showed enlargements of the air space (Lm: mean chord length) following irradiation. 40.563.8 mm and 60.066.9 mm were observed after one and four days, respectively, compared to 26.5 63.1 mm in normal mice. Three-dimensional micro-CT images were constructed and histograms of radiodensity - Hounsfield Units (HU) - were used to assess changes in mouse lungs. Radiation-induced lung injury was observed in irradiated mice, by the use of two parameters which were defined as shifts in peak HU between 2200 to 2800 HU (PeakHU) and increase in the number of pixels at 21000 HU (Number-1000). These parameters were correlated with histological changes. The results demonstrate that micro-CT can be used for the early de
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