有哪些信誉好的足球投注网站dendritic cells control cd4+cd25+ treg cell suppressor function in vitro through juxtacrine delivery of il-2树突细胞cd4 + cd25 + treg细胞抑制控制功能通过juxtacrine交付- 2体外.pdfVIP
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dendriticcellscontrolcd4cd25tregcellsuppressorfunctioninvitrothroughjuxtacrinedeliveryofil-2树突细胞cd4cd25treg细胞抑制控制功能通过juxtacrine交付-2体外
+ + Dendritic Cells Control CD4 CD25 Treg Cell Suppressor Function In Vitro through Juxtacrine Delivery of IL-2 2 1 1 1,2 Katarina Kulhankova , Todd Rouse , Mohamed E. Nasr , Elizabeth H. Field * 1 Department of Veterans Affairs Medical Center, Iowa City, Iowa, United States of America, 2 Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, United States of America Abstract + + + CD4 CD25 Foxp3 regulatory T cells (Tregs) restrict inflammatory responses to self and nonself. Aberrant Treg activity is pathologic: Insufficient Treg activity is implicated in autoimmunity, allergy, and graft-versus-host-disease; overabundant activity is implicated in chronic infection and cancer. Tregs require IL-2 for their expansion and acquisition/execution of suppressor function; however, because Tregs cannot produce IL-2, they depend on IL-2 from an exogenous source. Until now, that IL-2 source had not been established. We asked whether dendritic cells (DCs) could supply IL-2 to Tregs and, if so, what was required for that delivery. We used flow cytometry, IL-2 ELISPOT, RT-qPCR, and IL-2 promoter-driven reporter assays to measure intracytoplasmic IL-2, secreted protein, IL-2 message and IL-2 promoter activity in bone marrow-derived (BMDC) and splenic DCs. We examined conjugate formation between Tregs, conventional CD4+ cells, and IL-2-expressing DCs. We measured Treg levels of CD25, Foxp3, and suppressor function after co-culture with IL-2 sufficient and IL-2
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