有哪些信誉好的足球投注网站dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response树突细胞编辑通过激活自然杀伤细胞导致更多保护癌症特异性免疫反应.pdfVIP
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dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response树突细胞编辑通过激活自然杀伤细胞导致更多保护癌症特异性免疫反应
Dendritic Cell Editing by Activated Natural Killer Cells Results in a More Protective Cancer-Specific Immune Response 1. 2. 3 4 1,5 Barbara Morandi , Lorenzo Mortara , Laura Chiossone , Roberto S. Accolla , Maria Cristina Mingari , 3 1 6 Lorenzo Moretta , Alessandro Moretta , Guido Ferlazzo * 1 Department of Experimental Medicine, University of Genoa, Genoa, Italy, 2 Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy, 3 Istituto G.Gaslini, Genoa, Italy, 4 Department of Surgical and Morphological Sciences, University of Insubria, Varese, Italy, 5 Istituto Di Ricovero e Cura a Carattere Scientifico A.O.U. San Martino-IST-Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy, 6 Department of Human Pathology, University of Messina, Messina, Italy Abstract Over the last decade, several studies have extensively reported that activated natural killer (NK) cells can kill autologous immature dendritic cells (DCs) in vitro, whereas they spare fully activated DCs. This led to the proposal that activated NK cells might select a more immunogenic subset of DCs during a protective immune response. However, there is no demonstration that autologous DC killing by NK cells is an event occurring in vivo and, consequently, the functional relevance of this killing remains elusive. Here we report that a significant decrease of CD11c+ DCs was observed in draining lymph nodes of mice inoculated with MHC-devoid cells as NK cell targets able to induce NK cell activation. This in vivo DC editing by NK cells was perforin-dependent and it was fun
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