demand for zn2+ in acid-secreting gastric mucosa and its requirement for intracellular ca2+zn2 +需求acid-secreting胃粘膜及其胞内游离钙与要求.pdfVIP

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demand for zn2+ in acid-secreting gastric mucosa and its requirement for intracellular ca2+zn2 +需求acid-secreting胃粘膜及其胞内游离钙与要求.pdf

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demandforzn2inacid-secretinggastricmucosaanditsrequirementforintracellularca2zn2需求acid-secreting胃粘膜及其胞内游离钙与要求

Demand for Zn2+ in Acid-Secreting Gastric Mucosa and Its Requirement for Intracellular Ca2+ 1 1 1 2 2 JingJing Liu , Jonathan E. Kohler , Amy L. Blass , Juliet A. Moncaster , Anca Mocofanescu , Matthew A. 3,4 4 4 5 2,6 Marcus , Eleanor A. Blakely , Kathleen A. Bjornstad , Chitra Amarasiriwardena , Noel Casey , Lee E. 2,6. 1 . Goldstein , David I. Soybel * 1 Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Molecular Aging Development Laboratory, Boston University School of Medicine, Boston, Massachusetts, United States of America, 3 Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, 4 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America, 5 Channing Laboratories, Brigham and Women’s Hospital, Harvard Medical School, and the Harvard School of Public Health, Boston, Massachusetts, United States of America, 6 Center for Biometals and Metallomics, Boston University, Boston, Massachusetts, United States of America Abstract Background and Aims: Recent work has suggested that Zn2+ plays a critical role in regulating acidity within the secretory compartments of isolated gastric glands. Here, we investigate the content, distribution and demand for Zn2+ in gastric mucosa under baseline conditions and its regulation during secretory stimulation.