delineation of stage specific expression of plasmodium falciparum eba-175 by biologically functional region ii monoclonal antibodies界定阶段特定的表达恶性疟原虫eba - 175 ii单克隆抗体生物功能区域.pdfVIP

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delineation of stage specific expression of plasmodium falciparum eba-175 by biologically functional region ii monoclonal antibodies界定阶段特定的表达恶性疟原虫eba - 175 ii单克隆抗体生物功能区域.pdf

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delineation of stage specific expression of plasmodium falciparum eba-175 by biologically functional region ii monoclonal antibodies界定阶段特定的表达恶性疟原虫eba - 175 ii单克隆抗体生物功能区域

Delineation of Stage Specific Expression of Plasmodium falciparum EBA-175 by Biologically Functional Region II Monoclonal Antibodies 1 . 2. 3 1 4 B. Kim Lee Sim * , David L. Narum , Rana Chattopadhyay , Adriana Ahumada , J. David Haynes , 5 6 7 4 1,3 Steven R. Fuhrmann , Jennifer N. Wingard , Hong Liang , J. Kathleen Moch , Stephen L. Hoffman 1 Protein Potential LLC, Rockville, Maryland, United States of America, 2 Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America, 3 Sanaria Inc., Rockville, Maryland, United States of America, 4 U.S. Military Malaria Vaccine Program, Silver Spring, Maryland, United States of America, 5 Intercell USA, Gaithersburg, Maryland, United States of America, 6 Department of Molecular Physiology and Biophysics, University of Virginia, Charlottesville, Virginia, United States of America, 7 Infectious Disease Research Institute, Seattle, Washington, United States of America Abstract Background: The malaria parasite Plasmodium falciparum EBA-175 binds its receptor sialic acids on glycophorin A when invading erythrocytes. The receptor-binding region (RII) contains two cysteine-rich domains with similar cysteine motifs (F1 and F2). Functional relationships between F1 and F2 domains and characterization of EBA-175 were studied using specific monoclonal antibodies (mAbs) against these domains. Methods and Findings: Five mAbs specific for F1 or F2 were generated. Three mAbs specific for F