有哪些信誉好的足球投注网站delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking ctip2 in epidermis延迟皮肤伤口愈合和异常表达的毛囊干细胞标记小鼠有选择地缺乏ctip2表皮.pdfVIP
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delayed cutaneous wound healing and aberrant expression of hair follicle stem cell markers in mice selectively lacking ctip2 in epidermis延迟皮肤伤口愈合和异常表达的毛囊干细胞标记小鼠有选择地缺乏ctip2表皮
Delayed Cutaneous Wound Healing and Aberrant Expression of Hair Follicle Stem Cell Markers in Mice Selectively Lacking Ctip2 in Epidermis 1. 2. 1¤a 1 1 Xiaobo Liang , Shreya Bhattacharya , Gaurav Bajaj , Gunjan Guha , Zhixing Wang , Hyo-Sang Jang1¤b, Mark Leid1,2,3, Arup Kumar Indra1,2,3,4*, Gitali Ganguli-Indra1,2* 1 Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, United States of America, 2 Molecular and Cell Biology Program, Oregon State University, Corvallis, Oregon, United States of America, 3 Environmental Health Science Centre, Oregon State University, Corvallis, Oregon, United States of America, 4 Department of Dermatology, Oregon Health and Science University, Portland, Oregon, United States of America Abstract Background: COUP-TF interacting protein 2 [(Ctip2), also known as Bcl11b] is an important regulator of skin homeostasis, and is overexpressed in head and neck cancer. Ctip2ep 2/ 2 mice, selectively ablated for Ctip2 in epidermal keratinocytes, exhibited impaired terminal differentiation and delayed epidermal permeability barrier (EPB) establishment during development, similar to what was observed in Ctip2 null (Ctip22/ 2) mice. Considering that as an important role of Ctip2, and the fact that molecular networks which underlie cancer progression partially overlap with those responsible for tissue remodeling, we sought to determine the role of Ctip2 during cutaneous wound healing. Methodology/Principal Findings: Full thickness excisional wound healing experiments were performed on Ctip2L2/L2 and Ctip2ep 2/ 2 animals per time point and used for harvesting samples for histology, immunohistochemi
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