deficiency of the lim-only protein fhl2 reduces intestinal tumorigenesis in apc mutant mice缺乏lim-only fhl2蛋白减少肠道apc突变小鼠体内肿瘤发生.pdfVIP

Deficiency of the LIM-Only Protein FHL2 Reduces Intestinal Tumorigenesis in Apc Mutant Mice 1,2. ¨ 1,2. 1,2 3,4 5 Charlotte Labalette , Yann Nouet , Florence Levillayer , Sabine Colnot , Ju Chen , Valere 6 7 3,4 1,2 1,2 Claude , Michel Huerre , Christine Perret , Marie-Annick Buendia , Yu Wei * ´ ´ ´ 1 Departement de Virologie, Institut Pasteur, Paris, France, 2 Inserm U579, Paris, France, 3 Departement d’Endocrinologie Metabolisme et Cancer, Institut Cochin, Paris, ´ France, 4 Inserm U567, Paris, France, 5 Department of Medicine, University of California San Diego, La Jolla, California, United States of America, 6 Departement ˆ ´ ´ ´ ´ d’Anapathologie, Hopital Begin, Saint Mande, France, 7 Departement d’Infection et Epidemiologie, Institut Pasteur, Paris, France Abstract Background: The four and a half LIM-only protein 2 (FHL2) is capable of shuttling between focal adhesion and nucleus where it signals through direct interaction with a number of proteins including b-catenin. Although FHL2 activation has been found in various human cancers, evidence of its functional contribution to carcinogenesis has been lacking. Methodology/Principal Findings: Here we have