default network deactivations are correlated with psychopathic personality traits默认网络失活与心理变态的性格特征.pdfVIP

Default Network Deactivations Are Correlated with Psychopathic Personality Traits 1,2 4 1,3 Tong Sheng *, Anahita Gheytanchi , Lisa Aziz-Zadeh 1 Brain and Creativity Institute, University of Southern California, Los Angeles, California, United States of America, 2 Neuroscience Graduate Program, University of Southern California, Los Angeles, California, United States of America, 3 Division of Occupational Science and Occupational Therapy, University of Southern California, Los Angeles, California, United States of America, 4 Pacific Graduate School of Psychology, Palo Alto, California, United States of America Abstract Background: The posteromedial cortex (PMC) and medial prefrontal cortex (mPFC) are part of a network of brain regions that has been found to exhibit decreased activity during goal-oriented tasks. This network is thought to support a baseline of brain activity, and is commonly referred to as the ‘‘default network’’. Although recent reports suggest that the PMC and mPFC are associated with affective, social, and self-referential processes, the relationship between these default network components and personality traits, especially those pertaining to social context, is poorly understood. Methodology/Principal Findings: In the current investigation, we assessed the relationship between PMC and mPFC deactivations and psychopathic personality traits using fMRI and a self-report measure. We found that PMC deactivations predicted traits related to egocentricity and mPFC deactivations predicted traits related to decision-making. Conclusions/Significance: These results suggest that the PMC and mPFC are associated with processes involving self- relevancy and affective decision-making, consistent with previous reports. More ge