cytokinome profile of patients with type 2 diabetes andor chronic hepatitis c infectioncytokinome的2型糖尿病患者和或慢性丙型肝炎感染.pdfVIP

Cytokinome Profile of Patients with Type 2 Diabetes and/ or Chronic Hepatitis C Infection 1 1 1 2 1 Susan Costantini *, Francesca Capone , Eliana Guerriero , Raffaele Marfella , Angela Sorice , 3 4 2 1 5 Patrizia Maio , Michele Di Stasio , Giuseppe Paolisso , Giuseppe Castello , Giovanni Colonna 1 INT ‘‘G. Pascale’’ - Oncology Research Centre of Mercogliano, Mercogliano, Italy, 2 Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, ` Italy, 3 Unita Operativa Malattie Infettive, Azienda Ospedaliera di Rilievo Nazionale ‘‘San Giuseppe Moscati’’, Avellino, Italy, 4 Institute of Food Science - CNR, Avellino, Italy, 5 Department of Biochemistry and Biophysics and Interdepartmental Research Center for Computational and Biotechnological Sciences, Second University of Naples, Naples, Italy Abstract Both type 2 diabetes (T2D) and chronic hepatitis C (CHC) infection are associated with increased risk of developing hepatocellular carcinoma (HCC). Cytokines are known to play an important role not only in the mechanisms of insulin resistance and glucose disposal defects but also in the pathological processes occurring in the liver during viral infection. We evaluated the serum levels of many cytokines, chemokines, adipokines and growth factors in patients with type 2 diabetes, CHC, CHC-related cirrhosis, CHC and type 2 diabetes and CHC-related cirrhosis and type 2 diabetes by BioPlex assay. The obtained data evidenced that the serum levels of some proteins are significantly up-regulated in all the patients or in those with only