cysteine-rich secretory protein-3 (crisp3) is strongly up-regulated in prostate carcinomas with the tmprss2-erg fusion genecysteine-rich分泌蛋白质3(crisp3)强烈上调tmprss2-erg融合基因在前列腺癌.pdfVIP

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cysteine-rich secretory protein-3 (crisp3) is strongly up-regulated in prostate carcinomas with the tmprss2-erg fusion genecysteine-rich分泌蛋白质3(crisp3)强烈上调tmprss2-erg融合基因在前列腺癌.pdf

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cysteine-rich secretory protein-3 (crisp3) is strongly up-regulated in prostate carcinomas with the tmprss2-erg fusion genecysteine-rich分泌蛋白质3(crisp3)强烈上调tmprss2-erg融合基因在前列腺癌

Cysteine-Rich Secretory Protein-3 (CRISP3) Is Strongly Up-Regulated in Prostate Carcinomas with the TMPRSS2-ERG Fusion Gene 1,3,6,7. 1,3,6,7. 1,4,6,7 ˜ 1,3 ˜ Franclim R. Ribeiro , Paula Paulo , Vera L. Costa , Joao D. Barros-Silva , Joao Ramalho- 1,4 ´ 1,4,5 2,4,5 6,7 6,7 Carvalho , Carmen Jeronimo , Rui Henrique , Guro E. Lind , Rolf I. Skotheim , Ragnhild A. Lothe6,7, Manuel R. Teixeira1,3,5,7* 1 Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, 2 Department of Pathology, Portuguese Oncology Institute-Porto, Porto, Portugal, 3 Cancer Genetics Group, Research Centre of the Portuguese Oncology Institute-Porto, Porto, Portugal, 4 Cancer Epigenetics Group, Research Centre of the Portuguese Oncology Institute, Porto, Portugal, 5 Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal, 6 Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway, 7 Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway Abstract A large percentage of prostate cancers harbor TMPRSS2-ERG gene fusions, leading to aberrant overexpression of the transcription factor ERG. The target genes deregulated by this rearrangement, however, remain mostly unknown. To address this subject we performed genome-wide mRNA expression analysis on 6 non-malignant prostate samples and 24 prostate carcinomas with (n = 16) and without (n = 8)