cyp1a1 induction in the colon by serum involvement of the pparα pathway and evidence for a new specific human ppreα sitecyp1a1感应在结肠内的血清参与pparα通路和证据为一个新的特定人类ppreα网站.pdfVIP
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cyp1a1 induction in the colon by serum involvement of the pparα pathway and evidence for a new specific human ppreα sitecyp1a1感应在结肠内的血清参与pparα通路和证据为一个新的特定人类ppreα网站
CYP1A1 Induction in the Colon by Serum: Involvement of the PPARa Pathway and Evidence for a New Specific Human PPREa Site 1,2 3 1,2 1,2 4 Pierre-Henri Villard *, Fabrice Barlesi , Martine Armand , Thi-Mai-Anh Dao , Jean-Marc Pascussi , 1,2 1,2 5 ` 5 1,2 Francis Fouchier , Serge Champion , Claire Dufour , Christian Ginies , Ayman Khalil , Marie-Josephe Amiot1,2, Yves Barra1,2, Eric Seree1,2* ´ ´ ´ ´ ´ ´ ´ 1 INRA, UMR1260, Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France, 2 Faculte de Medecine, Universite de la Mediterranee Aix-Marseille 2, ´ ´ ´ ˆ IPHM-IFR 125, Marseille, France, 3 Thoracic Oncology, Universite de la Mediterranee – Assistance Publique Hopitaux de Marseille, Marseille, France, 4 Institut de Recherche ´ ´ pour le Developpement, UMR 5096 (CNRS-IRD-Universite Perpignan), Montpellier, France, 5 UMR 408 Safety and Quality of Plant Products, INRA, University of Avignon, Site Agroparc, Avignon, France Abstract Background: We previously showed that blood serum induced cytochrome P450 1A1 (CYP1A1) monooxygenase expression in vitro. Objective: Our purpose was (i) to identify the molecular mechanism involved and (ii) to characterize the inducer compound(s) in serum in
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