cyclodepsipeptides from marine sponges natural agents for drug research从海绵中cyclodepsipeptides天然药物药物研究.pdfVIP

Mar. Drugs 2010, 8, 810-834; doi:10.3390/md8030810 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Review Cyclodepsipeptides from Marine Sponges: Natural Agents for Drug Research Gowri Shankar Bagavananthem Andavan and Rosa Lemmens-Gruber * Department of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria; E-Mail: gowri.bagavananthem.andavan@univie.ac.at * Author to whom correspondence should be addressed; E-Mail: rosa.lemmens@univie.ac.at; Tel.: +43-1-4277-55325; Fax: +43-1-4277-9553. Received: 5 February 2010; in revised form: 4 March 2010 / Accepted: 19 March 2010 / Published: 22 March 2010 Abstract: A number of natural products from marine sponges, such as cyclodepsipeptides, have been identified. The structural characteristics of this family of cyclic peptides include various unusual amino acid residues and unique N-terminal polyketide-derived moieties. Papuamides are representatives of a class of marine sponge derived cyclic depsipeptides, including callipeltin A, celebesides A and B, homophymine A, mirabamides, microspinosamide, neamphamide A and theopapuamides. They are thought to have cytoprotective activity against HIV-1 in vitro by inhibiting viral entry. Jasplakinolide, a representative member of marine sponge-derived cyclodepsipeptides that include arenastatin A, geodiamolides, homophymines, spongidepsin and theopapuamides, is a