cyclodextrin inclusion complex to improve physicochemical properties of herbicide bentazon exploring better formulations环糊精包含复杂的除草剂苯改善理化性质探索更好的配方.pdfVIP

Cyclodextrin Inclusion Complex to Improve Physicochemical Properties of Herbicide Bentazon: Exploring Better Formulations ´ ˜ 1 ˜ 1 1 ´ 1 ´ 2 Claudia Yanez *, Paulina Canete-Rosales , Juan Pablo Castillo , Nicole Catalan , Tomas Undabeytia , Esmeralda Morillo2 ´ ´ ´ ´ ´ 1 Departamento de Quımica Organica y Fisicoquımica, Facultad de Ciencias Quımicas y Farmaceuticas, Universidad de Chile, Santiago, Chile, 2 Instituto de Recursos ´ ´ ˜ Naturales y Agrobiologıa, Consejo Superior de Investigaciones Cientıficas, Sevilla, Espana Abstract The knowledge of the host-guest complexes using cyclodextrins (CDs) has prompted an increase in the development of new formulations. The capacity of these organic host structures of including guest within their hydrophobic cavities, improves physicochemical properties of the guest. In the case of pesticides, several inclusion complexes with cyclodextrins have been reported. However, in order to explore rationally new pesticide formulations, it is essential to know the effect of cyclodextrins on the properties of guest molecules. In this study, the inclusion complexes of bentazon (Btz) with native bCD and two derivatives, 2-hydroxypropyl-b-cyclodextrin (HPCD) and sulfobutylether-b-cyclodextrin (SBECD), were prepared by two methods: kneading and freeze-drying, and their characterization was investigated with different analytical techniques including Fourier transform infrared spectroscopy (FT-IR), differential thermal analysis (DTA), X-ray diffract