有哪些信誉好的足球投注网站curcumin protects intestinal mucosal barrier function of rat enteritis via activation of mkp-1 and attenuation of p38 and nf-κb activation姜黄素可以保护肠粘膜屏障功能的老鼠通过激活mkp-1肠炎和衰减p38和nf-κb激活.pdfVIP
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curcumin protects intestinal mucosal barrier function of rat enteritis via activation of mkp-1 and attenuation of p38 and nf-κb activation姜黄素可以保护肠粘膜屏障功能的老鼠通过激活mkp-1肠炎和衰减p38和nf-κb激活
Curcumin Protects Intestinal Mucosal Barrier Function of Rat Enteritis via Activation of MKP-1 and Attenuation of p38 and NF-kB Activation 1 . 2. 3 4 1 1 Wei-Bing Song * , Yuan-Yuan Wang , Fan-Su Meng , Qing-Hua Zhang , Jian-Ying Zeng , Li-Ping Xiao , 1 1 1 2 2 Xin-Pei Yu , Dan-dan Peng , Lei Su , Bing Xiao , Zhen-Shu Zhang 1 Department of Gerontology, General Hospital of Guangzhou Military Command of People’s Liberation Army, Guangzhou, China, 2 Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China, 3 Department of Intensive Care Unit, Traditional Chinese Medical Hospital of ZhongSan City, Zhongshan, China, 4 Department of Gerontology, 458 Hospital of People’s Liberation Army, Guangzhou, China Abstract Background: Intestinal mucosa barrier (IMB) dysfunction results in many notorious diseases for which there are currently few effective treatments. We studied curcumin’s protective effect on IMB and examined its mechanism by using methotrexate (MTX) induced rat enteritis model and lipopolysaccharide (LPS) treated cell death model. Methodology/Principal Findings: Curcumin was intragastrically administrated from the first day, models were made for 7 days. Cells were treated with curcumin for 30 min before exposure to LPS. Rat intestinal mucosa was collected for evaluation of pathological changes. We detected the activities of D-lactate and diamine oxidase (DAO) according to previous research and measured the levels of myeloperoxidase (
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