cumulative epigenetic abnormalities in host genes with viral and microbial infection during initiation and progression of malignant lymphomaleukemia累计表观遗传异常与病毒和微生物感染宿主基因在恶性lymphomaleukemia的发生和发展.pdfVIP
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cumulative epigenetic abnormalities in host genes with viral and microbial infection during initiation and progression of malignant lymphomaleukemia累计表观遗传异常与病毒和微生物感染宿主基因在恶性lymphomaleukemia的发生和发展
Cancers 2011, 3, 568-581; doi:10.3390/cancers3010568 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Review Cumulative Epigenetic Abnormalities in Host Genes with Viral and Microbial Infection during Initiation and Progression of Malignant Lymphoma/Leukemia 1, 2 3 4 1 Takashi Oka *, Hiaki Sato , Mamoru Ouchida , Atae Utsunomiya and Tadashi Yoshino 1 Department of Pathology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mail: yoshino@md.okayama-u.ac.jp 2 Department of Medical Technology, Graduate School of Health Science, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mail: hiaki@md.okayama-u.ac.jp 3 Department of Molecular Genetics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mail: ouchidam@md.okayama-u.ac.jp 4 Department of Hematology, Imamura Bun-in Hospital, 11-23 Kamoike Shinnmachi, Kagoshima, 890-0064, Japan; E-Mail: autsunomiya@jiaikai.jp * Author to whom correspondence should be addressed; E-Mail: oka@md.okayama-u.ac.jp; Tel: +81-86-235-7101; Fax: +81-86-235-7156. Received: 31 December 2010; in revised form: 25 January 2011 / Accepted: 25 January 2011 / Published: 4 February 2011 Abstract: Although cancers have been thought to be predominantly driven by acquired genetic changes, it is becoming clea
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