conversion of the base prion strain into the bse strain the origin of bse基本朊病毒株转化为疯牛病病毒疯牛病的起源.pdfVIP

Conversion of the BASE Prion Strain into the BSE Strain: The Origin of BSE? 1 2 1 1 1 1 Raffaella Capobianco , Cristina Casalone , Silvia Suardi , Michela Mangieri , Claudia Miccolo , Lucia Limido , 1 1 1 1 1 1 Marcella Catania , Giacomina Rossi , Giuseppe Di Fede , Giorgio Giaccone , Maria Grazia Bruzzone , Ludovico Minati , 2 2 3 3 4 4 Cristiano Corona , Pierluigi Acutis , Daniela Gelmetti , Guerino Lombardi , Martin H. Groschup , Anne Buschmann , 5 5 2 1* Gianluigi Zanusso , Salvatore Monaco , Maria Caramelli , Fabrizio Tagliavini 1 Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Italy, 2 Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy, 3 Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Brescia, Italy, 4 Friedrich-Loeffler-Institut, Institute for Novel and Emerging Infectious Diseases, Greifswald, Insel Riems, Germany, 5 Department of Neurological and Visual Science, Section of Clinical Neurology, Policlinico G. B. Rossi, Verona, Italy Atypical neuropathological and molecular phenotypes of bovine spongiform encephalopathy (BSE) have recently been identified in different countries. One of these phenotypes, named bovine ‘‘amyloidotic’’ spongiform encephalopathy (BASE), differs from classical BSE for the occurrence of a distinct type of the disease-associated prion protein (PrP), termed PrPSc, and the presence of PrP amyloid plaques. Here, we