coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic serthr kinase pim-1协调表达的转录变弱tristetraprolin致癌serthr激酶pim-1的促有丝分裂的感应.pdfVIP

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coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic serthr kinase pim-1协调表达的转录变弱tristetraprolin致癌serthr激酶pim-1的促有丝分裂的感应.pdf

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coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic serthr kinase pim-1协调表达的转录变弱tristetraprolin致癌serthr激酶pim-1的促有丝分裂的感应

Coordinated Expression of Tristetraprolin Post- Transcriptionally Attenuates Mitogenic Induction of the Oncogenic Ser/Thr Kinase Pim-1 1. 1. 1 1 Dig B. Mahat , Sarah E. Brennan-Laun , Elizabeth J. Fialcowitz-White , Aparna Kishor , Christina R. 1 1 4 5 2,3 1,3 Ross , Tatyana Pozharskaya , J. David Rawn , Perry J. Blackshear , Bret A. Hassel , Gerald M. Wilson * 1 Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 2 Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 3 Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, United States of America, 4 Department of Chemistry, Towson University, Baltimore, Maryland, United States of America, 5 Laboratory of Signal Transduction, NIEHS-NIH, Research Triangle Park, North Carolina, United States of America Abstract The serine/threonine kinase Pim-1 directs selected signaling events that promote cell growth and survival and is overexpressed in diverse human cancers. Pim-1 expression is tightly controlled through multiple mechanisms, including regulation of mRNA turnover. In several cultured cell models, mitogenic stimulation rapidly induced and stabilized PIM1 mRNA, however, vigorous destabilization 4–6 hours later helped restore basal expression levels. Acceleration of PIM1 mRNA turnover coincided with accumulation of tris