有哪些信誉好的足球投注网站cooperative interaction between the muc1-c oncoprotein and the rab31 gtpase in estrogen receptor-positive breast cancer cells合作互动muc1-c癌蛋白和rab31 gtpase雌激素受体阳性乳腺癌细胞.pdfVIP
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cooperative interaction between the muc1-c oncoprotein and the rab31 gtpase in estrogen receptor-positive breast cancer cells合作互动muc1-c癌蛋白和rab31 gtpase雌激素受体阳性乳腺癌细胞
Cooperative Interaction between the MUC1-C Oncoprotein and the Rab31 GTPase in Estrogen Receptor-Positive Breast Cancer Cells 1 1 2 3 1 2 Caining Jin , Hasan Rajabi , Sean Pitroda , Ailing Li , Akriti Kharbanda , Ralph Weichselbaum , Donald Kufe1* 1 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, United States of America, 3 Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America Abstract Rab31 is a member of the Ras superfamily of small GTPases that has been linked to poor outcomes in patients with breast cancer. The MUC1-C oncoprotein is aberrantly overexpressed in most human breast cancers and also confers a poor prognosis. The present results demonstrate that MUC1-C induces Rab31 expression in estrogen receptor positive (ER+) breast cancer cells. We show that MUC1-C forms a complex with estrogen receptor a (ERa) on the Rab31 promoter and activates Rab31 gene transcription in an estrogen-dependent manner. In turn, Rab31 contributes to the upregulation of MUC1-C abundance in breast cancer cells by attenuating degradation of MUC1-C in lysosomes. Expression of an inactive Rab31(S20N) mutant in nonmalignant breast epithelial cells confirmed that Rab31 regulates MUC1-C expression. The functional significance of the MUC1-C/Rab31 interaction is supported by the demonstration that Rab31 confers the formation of mammospheres by a MUC1-C-dependent mechanism. Analysis of microarray databases further showed that (i) Rab31 is expressed a
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