有哪些信誉好的足球投注网站contribution by polymorphonucleate granulocytes to elevated gamma-glutamyltransferase in cystic fibrosis sputum贡献的polymorphonucleate粒细胞在囊性纤维化痰gamma-glutamyltransferase升高.pdfVIP
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contribution by polymorphonucleate granulocytes to elevated gamma-glutamyltransferase in cystic fibrosis sputum贡献的polymorphonucleate粒细胞在囊性纤维化痰gamma-glutamyltransferase升高
Contribution by Polymorphonucleate Granulocytes to Elevated Gamma-Glutamyltransferase in Cystic Fibrosis Sputum 1 2,3 4 5,6 1 Alessandro Corti *, Maria Franzini , Silvana Cianchetti , Gabriella Bergamini , Evelina Lorenzini , 5 1,3 4 1 Paola Melotti , Aldo Paolicchi , Pierluigi Paggiaro , Alfonso Pompella ` 1 Dipartimento di Patologia Sperimentale, Universita di Pisa, Scuola Medica, Pisa, Italy, 2 Scuola Superiore S. Anna, Pisa, Italy, 3 Fondazione Toscana G. Monasterio, CNR, ` Regione Toscana, Pisa, Italy, 4 Dipartimento Cardio Toracico e Vascolare, Universita di Pisa, Pisa, Italy, 5 Centro Fibrosi Cistica, Azienda Ospedaliera di Verona, Verona, Italy, ` 6 Dipartimento di Patologia e Diagnostica, Universita di Verona, Verona, Italy Abstract Background: Cystic fibrosis (CF) is an autosomal recessive disorder characterized by a chronic neutrophilic airways inflammation, increasing levels of oxidative stress and reduced levels of antioxidants such as glutathione (GSH). Gamma- glutamyltransferase (GGT), an enzyme induced by oxidative stress and involved in the catabolism of GSH and its derivatives, is increased in the airways of CF patients with inflammation, but the possible implications of its increase have not yet been investigated in detail. Principal Findings: The present study was aimed to evaluate the origin and the biochemical characteri
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