comparison of tnfα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs trovafloxacin as an example比较tnfα脂多糖作为inflammagen的特殊药物肝毒性的潜在trovafloxacin为例.pdfVIP
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comparison of tnfα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs trovafloxacin as an example比较tnfα脂多糖作为inflammagen的特殊药物肝毒性的潜在trovafloxacin为例
Int. J. Mol. Sci. 2010, 11, 4697-4714; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example Michael J. Liguori 1,*, Amy C. Ditewig 1, Jane F. Maddox 2, James P. Luyendyk 2,†, 3 4 3 1 Lois D. Lehman-McKeeman , David M. Nelson , Vasanthi M. Bhaskaran , Jeffrey F. Waring , 2 2 1 Patricia E. Ganey , Robert A. Roth and Eric A. G. Blomme 1 Department of Cellular, Molecular, Exploratory Toxicology, Abbott Laboratories; Abbott Park, IL 60064, USA; E-Mails: amy.ditewig@ (A.C.D.); jeff.waring@ (J.F.W.); eric.blomme@ (E.A.G.B.) 2 Department of Pharmacology Toxicology, Center for Integrative Toxicology, Michigan State University; East Lansing, MI 48824, USA; E-Mails: maddox@ (J.F.M.); jluyendyk@ (J.P.L.); ganey@ (P.E.G.); rothr@ (R.A.R.) 3 Discovery Toxicology, Bristol-Myers Squibb; Princeton, NJ 08540, USA; E-Mail: lois.lehman-mckeeman@ (L.D.L.-M.); vasanthi.bhaskaran@ (V.M.B.) 4 The Beatson Institute for Cancer Research, Glasgow, UK; E-Mail: d.nelson@beatson.gla.ac.uk † Current address: Department of Pharmacology, Toxicology and Therapeutics, The University of
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