combined phosphatase and tensin homolog (pten) loss and fatty acid synthase (fas) overexpression worsens the prognosis of chinese patients with hepatocellular carcinoma磷酸酶和tensin同族体(pten)损失和脂肪酸合酶(fas)过度恶化中国的肝细胞癌患者的预后.pdfVIP
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combined phosphatase and tensin homolog (pten) loss and fatty acid synthase (fas) overexpression worsens the prognosis of chinese patients with hepatocellular carcinoma磷酸酶和tensin同族体(pten)损失和脂肪酸合酶(fas)过度恶化中国的肝细胞癌患者的预后
Int. J. Mol. Sci. 2012, 13, 9980-9991; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma Xuehua Zhu 1,†, Xia Qin 2,3,†, Maogui Fei 4,†, Wenmin Hou 4, Joel Greshock 3, Kurtis E. Bachman 3, Richard Wooster 3, Jiuhong Kang 1,* and Crystal Ying Qin 2,3,* 1 Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai 200092, China; E-Mail: huahuazxh@ 2 Department of Oncology, GlaxoSmithKline Research and Development Center, Shanghai 201203, China; E-Mail: xia.x.qin@ 3 Cancer Research, GlaxoSmithKline, Collegeville, PA 19426, USA; E-Mails: joel.d.greshock@ (J.G.); kurtis.e.bachman@ (K.E.B.); richard.f.wooster@ (R.W.) 4 Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of CAS, Chinese Academy of Sciences, Shanghai 200031, China; E-Mails: mgfei@ (M.F.); wmhou@ (W.H.) † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: jhkang@ (J.K.); crystal.y.qin@ (C.Y.Q.); Tel.: +86-21-6598-8876 (J.K.); +86-21-6159-0908 (C.Y.Q.); Fax: +86-21-6598-1041 (J.K.); +86-21-6159-0700 (C.Y.Q.). Received: 12 June 2012; in revised form: 26 July 2012 / Accepted: 1 August 2012 / Published: 10 August 2012 Ab
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