combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease伐和阿托伐他汀联合治疗,定期锻炼提高冠状动脉疾病患者的动脉壁刚度.pdfVIP
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combination treatment of rosuvastatin or atorvastatin, with regular exercise improves arterial wall stiffness in patients with coronary artery disease伐和阿托伐他汀联合治疗,定期锻炼提高冠状动脉疾病患者的动脉壁刚度
Combination Treatment of Rosuvastatin or Atorvastatin, with Regular Exercise Improves Arterial Wall Stiffness in Patients with Coronary Artery Disease 1,2,3 1 3 4 5 6 Kensuke Toyama , Seigo Sugiyama *, Hideki Oka , Yuri Iwasaki , Hitoshi Sumida , Tomoko Tanaka , 3,6 6 1 Shinji Tayama , Hideaki Jinnouchi , Hisao Ogawa 1 Faculty of Life Science, Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan, 2 Research Fellowship of the Japan Society for the Promotion of Science, Tokyo, Japan, 3 Division of Cardiology, Health Insurance Hitoyoshi General Hospital, Kumamoto, Japan, 4 Clinical Research Center, Health Insurance Hitoyoshi General Hospital, Kumamoto, Japan, 5 Division of Cardiology, Kumamoto Central Hospital, Kumamoto, Japan, 6 Division of Preventive Cardiology, Department of Cardiovascular Medicine, Kumamoto University Hospital, Kumamoto, Japan Abstract Objective: Statin- and exercise-therapy are both clinically beneficial by preventing cardiovascular events in patients with coronary artery disease (CAD). However, there is no information on the vascular effects of the combination of statins and exercise on arterial wall stiffness in CAD patients. Methods: The present study is a sub-analysis of PRESET study that determined the effects of 20-week treatment with statins (rosuvastatin, n = 14, atorvastatin, n = 14) combined with regular exercise on arterial wall stiffness assessed by measurement of brachial and ankle pulse wave velocity (baPWV) in CAD patients. Results: The combination of statins and regular exercise significantly improved exercise capacity, lipid profile, including low- and high
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