有哪些信誉好的足球投注网站colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy结直肠癌干细胞是富含异基因的肿瘤化疗后.pdfVIP
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colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy结直肠癌干细胞是富含异基因的肿瘤化疗后
Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy 1 1 1 1 1 1 Scott J. Dylla *, Lucia Beviglia , In-Kyung Park , Cecile Chartier , Janak Raval , Lucy Ngan , Kellie 1 1 1 1 2 1 Pickell , Jorge Aguilar , Sasha Lazetic , Stephanie Smith-Berdan , Michael F. Clarke , Tim Hoey , John Lewicki1, Austin L. Gurney1 1 OncoMed Pharmaceuticals Inc., Redwood City, California, United States of America, 2 Stanford Institute for Stem Cell Biology Regenerative Medicine, Stanford University, Palo Alto, California, United States of America Abstract Background: Patients generally die of cancer after the failure of current therapies to eliminate residual disease. A subpopulation of tumor cells, termed cancer stem cells (CSC), appears uniquely able to fuel the growth of phenotypically and histologically diverse tumors. It has been proposed, therefore, that failure to effectively treat cancer may in part be due to preferential resistance of these CSC to chemotherapeutic agents. The subpopulation of human colorectal tumor cells with an ESA+CD44+ phenotype are uniquely responsible for tumorigenesis and have the capacity to generate heterogeneous tumors in a xenograft setting (i.e. CoCSC). We hypothesized that if non-tumorigenic cells are more susceptible to chemotherapeutic agents, then residual tumors might be expected to contain a higher frequency of CoCSC.
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