biodegradable metals for cardiovascular stent application interests and new opportunities生物可降解金属对心血管支架应用的利益和新的机遇.pdfVIP

biodegradable metals for cardiovascular stent application interests and new opportunities生物可降解金属对心血管支架应用的利益和新的机遇.pdf

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biodegradable metals for cardiovascular stent application interests and new opportunities生物可降解金属对心血管支架应用的利益和新的机遇

Int. J. Mol. Sci. 2011, 12, 4250-4270; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Biodegradable Metals for Cardiovascular Stent Application: Interests and New Opportunities Maryam Moravej and Diego Mantovani * Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering University Hospital Research Center, Laval University, Québec City, G1V 0A6, Que., Canada; E-Mail: maryam.moravej.1@ulaval.ca * Author to whom correspondence should be addressed; E-Mail: diego.mantovani@gmn.ulaval.ca; Tel.: +1-418-656-213 ext. 6270; Fax: +1-418-656-5343. Received: 14 April 2011; in revised form: 15 June 2011 / Accepted: 19 June 2011 / Published: 29 June 2011 Abstract: During the last decade, biodegradable metallic stents have been developed and investigated as alternatives for the currently-used permanent cardiovascular stents. Degradable metallic materials could potentially replace corrosion-resistant metals currently used for stent application as it has been shown that the role of stenting is temporary and limited to a period of 6– 12 months after implantation during which arterial remodeling and healing occur. Although corrosion is generally considered as a failure in metallurgy, the corrodibility of certain metals can be an advantage for their application as degradable implants. The candidat

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