vitamin a enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kda laminin receptor维生素a可以增强抗肿瘤效果的绿茶多酚对黑色素瘤移植多酚传感分子67 kda层粘连蛋白受体.pdfVIP

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vitamin a enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kda laminin receptor维生素a可以增强抗肿瘤效果的绿茶多酚对黑色素瘤移植多酚传感分子67 kda层粘连蛋白受体.pdf

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vitamin a enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kda laminin receptor维生素a可以增强抗肿瘤效果的绿茶多酚对黑色素瘤移植多酚传感分子67 kda层粘连蛋白受体

Vitamin A Enhances Antitumor Effect of a Green Tea Polyphenol on Melanoma by Upregulating the Polyphenol Sensing Molecule 67-kDa Laminin Receptor 1 1 1 1 1,2 Ju Hye Lee , Mutsumi Kishikawa , Motofumi Kumazoe , Koji Yamada , Hirofumi Tachibana * 1 Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki, Japan, 2 Laboratory of Functional Food Design, Department of Functional Metabolic Design, Bio-Architecture Center, Kyushu University, Fukuoka, Japan Abstract Background: Green tea consumption has been shown to have cancer preventive qualities. Among the constituents of green tea, (-)-Epigallocatechin-3-O-gallate (EGCG) is the most effective at inhibiting carcinogenesis. However, the concentrations of EGCG that are required to elicit the anticancer effects in a variety of cancer cell types are much higher than the peak plasma concentration that occurs after drinking an equivalent of 2–3 cups of green tea. To obtain the anticancer effects of EGCG when consumed at a reasonable concentration in daily life, we investigated the combination effect of EGCG and food ingredient that may enhance the anticancer activity of EGCG on subcutaneous tumor growth in C57BL/6N mice challenged with B16 melanoma cells. Methodology/Principal Findings: All-trans-retinoic acid (ATRA) enhanced the expression of the 67-kDa laminin receptor (67LR) and increased EGCG-induced cell growth inhibition in B16 melanoma cells. The cell growth inhibition seen with the combined EGCG and ATRA treatment was abolished by treatment with an anti-67LR antibody. In addition, the combined EGCG and ATRA treatment significantly suppressed the melanoma tumor gr