visualizing early splenic memory cd8+ t cells reactivation against intracellular bacteria in the mouse可视化脾早期记忆cd8 + t细胞活化对胞内细菌的老鼠.pdfVIP

Visualizing Early Splenic Memory CD8+ T Cells Reactivation against Intracellular Bacteria in the Mouse ´ 1,2,3,4,5,6 1,2 ´ ´ 2,4 ´ 1,2,7 Marc Bajenoff *, Emilie Narni-Mancinelli , Frederic Brau , Gregoire Lauvau * ´ ´ ´ ´ 1 Institut National de la Sante et de la Recherche Medicale Unite 924, Groupe Avenir, Valbonne, France, 2 Universite de Nice-Sophia Antipolis, Nice, France, 3 Centre ´ ´ ´ d’Immunologie de Marseille-Luminy, INSERM, UMR-S 631, Marseille, France, 4 CNRS, UMR 6102, Marseille, France, 5 Universite de la Mediterranee, UM 631, Marseille, France, 6 CNRS-UMR6097, IPMC, Valbonne, France, 7 Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, New York, United States of America Abstract Memory CD8+ T cells represent an important effector arm of the immune response in maintaining long-lived protective immunity against viruses and some intracellular bacteria such as Listeria monocytogenes (L.m). Memory CD8+ T cells are endowed with enhanced antimicrobial effector functions that perfectly tail them to rapidly eradicate invading pathogens. It is largely accepted that these functions are sufficient to explain how memory CD8+ T cells can mediate rapid protection. However, it is important to point out that such improved functional features would be useless if memo