viability conditions for a compartmentalized protometabolic system a semi-empirical approach生存条件区分protometabolic系统一种半经验的方法.pdfVIP

Viability Conditions for a Compartmentalized Protometabolic System: A Semi-Empirical Approach 1 2,3 4 5 Gabriel Piedrafita , Kepa Ruiz-Mirazo , Pierre-Alain Monnard , Athel Cornish-Bowden , Francisco Montero1* ´ ´ ´ ´ 1 Departamento de Bioquımica y Biologıa Molecular I, Universidad Complutense de Madrid, Madrid, Spain, 2 Departamento de Logica y Filosofıa de la Ciencia, Universidad ´ ´ ´ ´ ´ del Paıs Vasco, Donostia-San Sebastian, Spain, 3 Unidad de Biofısica, Consejo Superior de Investigaciones Cientıficas-Universidad del Paıs Vasco, Leioa, Spain, 4 Center for ´ ´ ´ ´ ´ Fundamental Living Technology, University of Southern Denmark, Odense, Denmark, 5 Unite de Bioenergetique et Ingenierie des Proteines, Centre National de la Recherche Scientifique, Marseille, France Abstract In this work we attempt to find out the extent to which realistic prebiotic compartments, such as fatty acid vesicles, would constrain the chemical network dynamics that could have sustained a minimal form of metabolism. We combine experimental and simulation results to establish the conditions under which a reaction network with a catalytically closed organization (more specifically, an (M ,R)-system) would overcome the potential problem of self-suffocation that arises from the limited accessibility