variation in lpa is associated with lp(a) levels in three populations from the third national health and nutrition examination surveylpa的变化与lp(a)水平在三个人口第三次全国健康和营养调查.pdfVIP

Variation in LPA Is Associated with Lp(a) Levels in Three Populations from the Third National Health and Nutrition Examination Survey 1,2 1 1 3 3 Logan Dumitrescu , Kimberly Glenn , Kristin Brown-Gentry , Cynthia Shephard , Michelle Wong , 3 3 3 1,2 Mark J. Rieder , Joshua D. Smith , Deborah A. Nickerson , Dana C. Crawford * 1 Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America, 2 Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America, 3 Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America Abstract The distribution of lipoprotein(a) [Lp(a)] levels can differ dramatically across diverse racial/ethnic populations. The extent to which genetic variation in LPA can explain these differences is not fully understood. To explore this, 19 LPA tagSNPs were genotyped in 7,159 participants from the Third National Health and Nutrition Examination Survey (NHANES III). NHANES III is a diverse population-based survey with DNA samples linked to hundreds of quantitative traits, including serum Lp(a). Tests of association between LPA variants and transformed Lp(a) levels were performed across the three different NHANES subpopulations (non-Hispanic whites, non-Hispanic blacks, and Mexican Americans). At a significance threshold of p,0.0001, 15 of the 19 SNPs tested were strongly associated with Lp(a) levels in at least one subpopulation, six in at least two subpo