variants in a novel epidermal collagen gene (col29a1) are associated with atopic dermatitis一个新颖的表皮胶原蛋白基因的变异(col29a1)与过敏性皮肤炎有关.pdfVIP

PLoS BIOLOGY Variants in a Novel Epidermal Collagen Gene (COL29A1) Are Associated with Atopic Dermatitis ¨ ¨ 1,2[ 1,2[ 1,2 ¨ 2 1,2 Cilla Soderhall , Ingo Marenholz , Tamara Kerscher , Franz Ruschendorf , Jorge Esparza-Gordillo , 3 1 4 4 2 2 1 Margitta Worm , Christoph Gruber , Gabriele Mayr , Mario Albrecht , Klaus Rohde , Herbert Schulz , Ulrich Wahn , Norbert Hubner2, Young-Ae Lee1,2* ´ ¨ ¨ 1 Department of Pediatric Pneumology and Immunology, Charite Universitatsmedizin Berlin, Germany, 2 Max-Delbruck-Centrum for Molecular Medicine, Berlin, Germany, ´ ¨ ¨ 3 Department of Dermatology and Allergology, Charite Universitatsmedizin Berlin, Germany, 4 Max Planck Institute for Informatics, Saarbrucken, Germany Atopic dermatitis (AD) is a common chronic inflammatory skin disorder and a major manifestation of allergic disease. AD typically presents in early childhood often preceding the onset of an allergic airway disease, such as asthma or hay fever. We previously mapped a susceptibility locus for AD on Chromosome 3q21. To identify the underlying disease gene, we used a dense map of microsatellite markers and single nucleotide polymorphisms, and we detected association with AD. In concordance with the linkage results, we foun