有哪些信誉好的足球投注网站variant histone h2a.z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning组蛋白h2a变体。.pdfVIP
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variant histone h2a.z is globally localized to the promoters of inactive yeast genes and regulates nucleosome positioning组蛋白h2a变体。
Open access, freely available online PLoS BIOLOGY Variant Histone H2A.Z Is Globally Localized to the Promoters of Inactive Yeast Genes and Regulates Nucleosome Positioning ˆ 1[ 2[ ´ 1 1 3 2* Benoıt Guillemette , Alain R. Bataille , Nicolas Gevry , Maryse Adam , Mathieu Blanchette , Franc¸ois Robert , 1* Luc Gaudreau ´ ´ ´ ´ ´ 1 Centre de Recherche sur les Mecanismes du Fonctionnement Cellulaire, Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, ´ ´ ´ ´ Canada, 2 Laboratoire de Chromatine et Expression du Genome, Institut de Recherches Cliniques de Montreal, Montreal, Quebec, Canada, 3 McGill Center for Bioinformatics, ´ ´ Lyman Duff Medical Building, Montreal, Quebec, Canada H2A.Z is an evolutionary conserved histone variant involved in transcriptional regulation, antisilencing, silencing, and genome stability. The mechanism(s) by which H2A.Z regulates these various biological functions remains poorly defined, in part due to the lack of knowledge regarding its physical location along chromosomes and the bearing it has in regulating chromatin structure. Here we mapped H2A.Z across the yeast genome at an approximately 300-bp resolution, using chromatin immunoprecipitation combined with tiling microarrays. We have identified 4,862 small regions—typically one or two nu
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