the homeodomain-containing transcription factors arx and pax4 control enteroendocrine subtype specification in micehomeodomain-containing转录因子arx和pax4控制enteroendocrine亚型规范在老鼠身上.pdfVIP

The Homeodomain-Containing Transcription Factors Arx and Pax4 Control Enteroendocrine Subtype Specification in Mice 1 2,3 1 2,3 1 Anthony Beucher , Elisabet Gjernes , Caitlin Collin , Monica Courtney , Aline Meunier , 2,3 ´ 1 Patrick Collombat , Gerard Gradwohl * ´ ´ ´ ´ ´ 1 Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), Institut National de la Sante et de la Recherche Medicale (INSERM) U964, Centre National de ´ ´ Recherche Scientifique (CNRS) UMR 7104, Universite de Strasbourg, Illkirch, France, 2 INSERM UMR 636, Diabetes Genetics Team, Nice, France, 3 Universite de Nice-Sophia ´ ´ ´ Antipolis, Laboratoire de Genetique du Developpement Normal et Pathologique, Nice, France Abstract Intestinal hormones are key regulators of digestion and energy homeostasis secreted by rare enteroendocrine cells. These cells produce over ten different hormones including GLP-1 and GIP peptides known to promote insulin secretion. To date, the molecular mechanisms controlling the specification of the various enteroendocrine subtypes from multipotent Neurog3+ endocrine progenitor cells, as well as their number, remain largely unknown. In contrast, in the embryonic pancreas, the opposite activities of Arx and Pax4 homeodomain transcription factors promote islet progenitor cells towards the different endocrine cell