the great escape viral strategies to counter bst-2tetherin大逃亡病毒对抗bst-2tetherin策略.pdfVIP

Review The Great Escape: Viral Strategies to Counter BST-2/ Tetherin Janet L. Douglas, Jean K. Gustin, Kasinath Viswanathan, Mandana Mansouri, Ashlee V. Moses*, Klaus ¨ Fruh Vaccine and Gene Therapy Institute, Oregon Health Science University, Beaverton, Oregon, United States of America into the complexity of host–virus relationships and reminds us of Abstract: The interferon-induced BST-2 protein has the the potential to exploit these relationships for therapeutic benefit. unique ability to restrict the egress of HIV-1, Kaposi’s sarcoma–associated herpesvirus (KSHV), Ebola virus, and Molecular Characteristics of BST-2 other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells Membrane Topology of BST-2 led to the renaming of BST-2 as ‘‘tetherin’’. However, viral Human, rat, and mouse BST-2 have been independently identified proteins such as HIV-1 Vpu, simian immunodeficiency and subsequently cloned by several groups [2,6–8]. This work and virus Nef, and KSHV K5 counteract BST-2, thereby allowing that of others [9] revealed that bst-2 encodes a 20-kDa, single pass, mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has type II glycosylated membrane protein that localizes to lipid rafts via been an explosion of research into several aspects of this its COOH-terminal glycosylphosphatidylini