the genetic basis of alcoholism multiple phenotypes, many genes, complex networks酗酒多个表型的遗传基础,许多基因,复杂的网络.pdfVIP

Morozova et al. Genome Biology 2012, 13:239 /2012/13/2/239 R E V I E W The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks 1,2 3 2,4 1,2,4, Tatiana V Morozova , David Goldman , Trudy FC Mackay and Robert RH Anholt * 500  million East Asians [2]. Depression, epilepsy, Abstract hypertension and hemorrhagic stroke occur secondary to Alcoholism is a signicant public health problem. A alcohol consumption [3]. Finally, alcohol consumption picture of the genetic architecture underlying alcohol- during pregnancy can result in birth defects that comprise related phenotypes is emerging from genome-wide fetal alcohol syndrome [4]. e diversity of pathologic association studies and work on genetically tractable effects of alcohol indicates that this drug exerts toxicity model organisms. through multiple mechanisms, each of which can be Keywords Addiction, alcohol sensitivity, disease modulated by different genetic variants. susceptibility, genome-wide association studies, Twin studies have demonstrated that the amount of human genetics, model organisms. alcohol one consumes has a genetic influence [5]. Age at first drink appears to be associated with alcohol-related prob