the effect of monoterpenes on swarming differentiation and haemolysin activity in proteus mirabilis单萜的影响在变形杆菌群集分化和溶血素活动.pdfVIP

Molecules 2008, 13, 3107-3116; DOI: 10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Effect of Monoterpenes on Swarming Differentiation and Haemolysin Activity in Proteus mirabilis Sergio Echeverrigaray 1,*, Lessandra Michelim 1,2, Ana Paula Longaray Delamare 1, Cristiane Paim Andrade 1, Sérgio Olavo Pinto da Costa 1 and Jucimar Zacaria 1 1 Research Laboratory of Microbiology, Institute of Biotechnology, University of Caxias do Sul, Rua Francisco Getúlio Vargas, 1130, Caxias do Sul, Brazil 95070-560 2 Division of Infectious Diseases. General Hospital of Caxias do Sul, University of Caxias do Sul, Av. Prof Antonio Vignolli, 255, Caxias do Sul, Brazil95070-560; Email: lessandra@ (L. M.) * Author to whom correspondence should be addressed; E-mail: selaguna@ucs.br; Tel.: +55 54 Fax: +55 54 Received: 3 November 2008; in revised form: 19 November 2008 / Accepted: 27 November 2008 / Published: 15 December 2008 Abstract: Urinary tract infection by Proteus mirabilis depends on several virulence properties that are coordinately regulated with swarming differentiation. Here we report the antibacterial and anti-swarming effect of seventeen terpenoids, and the effect of sub- inhibitory concentrations of five selected terpenoids on swarming, biofilm formation and haemolysin activity. The results showed that all the terpenes evaluated, particularly oxygenated terpenoids, inhibited P. mir