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the distributions, mechanisms, and structures of metabolite-binding riboswitches分布、机制和结构metabolite-binding riboswitches.pdf

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the distributions, mechanisms, and structures of metabolite-binding riboswitches分布、机制和结构metabolite-binding riboswitches

Volume 8, Issue 11, Article R239Barrick and Breaker2007 Open Access Research The distributions, mechanisms, and structures of metabolite-binding riboswitches Jeffrey E Barrick*† and Ronald R Breaker*‡§ Addresses: *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8103, USA. †Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI48824-4320, USA. ‡Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06520-8103, USA. §Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, USA. Correspondence: Ronald R Breaker. Email: ronald.breaker@ Published: 12 November 2007 Received: 26 July 2007 Revised: 1 October 2007 Genome Biology 2007, 8:R239 (doi:10.1186/gb-2007-8-11-r239) Accepted: 12 November 2007 The electronic version of this article is the complete one and can be found online at /2007/8/11/R239 © 2007 Barrick and Breaker; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. led to updated aptamer structRiboswitch distribution, mechanisms and structurespPhylogenetic analyses revealed insights into the distribution of riboswitch classes in different microbial groups, and strucure models and insights into the mechanism of these non-coding RNA structures./p tural analyses Abstract Background: Riboswitches are noncoding RNA structures that app