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targeting oncogenic protein-protein interactions by diversity oriented synthesis and combinatorial chemistry approaches针对多样性导向合成和组合化学致癌蛋白质相互作用的方法.pdf

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targeting oncogenic protein-protein interactions by diversity oriented synthesis and combinatorial chemistry approaches针对多样性导向合成和组合化学致癌蛋白质相互作用的方法

Molecules 2011, 16, 4408-4427; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Targeting Oncogenic Protein-Protein Interactions by Diversity Oriented Synthesis and Combinatorial Chemistry Approaches Andreas G. Tzakos 1,2,*, Demosthenes Fokas 3, Charlie Johannes 4, Vassilios Moussis 2, Eleftheria Hatzimichael 5 and Evangelos Briasoulis 1,5,6,* 1 Human Cancer Biobank Center, University of Ioannina, Ioannina, GR-45110, Greece 2 Department of Chemistry, University of Ioannina, Ioannina, GR-45110, Greece 3 Department of Materials Science and Engineering, University of Ioannina, Ioannina, GR-45110, Greece 4 Institute for Chemistry and Engineering Sciences, 11 Biopolis Way, Helios, #03-08, Singapore 138667, Singapore 5 Department of Clinical Hematology,University Hospital of Ioannina, Ioannina, GR-45110, Greece 6 Medical School, Oncology Section, University of Ioannina, Ioannina, GR-45110, Greece * Author to whom correspondence should be addressed; E-Mails: ebriasou@otenet.gr (E.B.); atzakos@cc.uoi.gr (A.G.T.). Received: 10 March 2011; in revised form: 4 May 2011 / Accepted: 25 May 2011 / Published: 27 May 2011 Abstract: We are currently witnessing a decline in the development of efficient new anticancer drugs, despite the salient efforts made on all fronts of cancer drug discovery. This trend presumably relates to the substantial heterogeneity and the inherent biological complexity of cancer, which hinder drug development success. Protein-protein interactions (PPIs) are key p