有哪些信誉好的足球投注网站tam receptor ligands in lupus protein s but not gas6 levels reflect disease activity in systemic lupus erythematosustam受体配体在狼疮蛋白s但不是gas6水平反映在系统性红斑狼疮疾病活动.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
tam receptor ligands in lupus protein s but not gas6 levels reflect disease activity in systemic lupus erythematosustam受体配体在狼疮蛋白s但不是gas6水平反映在系统性红斑狼疮疾病活动
Suh et al. Arthritis Research Therapy 2010, 12:R146 /content/12/4/R146 RESEARCH ARTICLE Open Access TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus 1,2 1 1 3 1* Chang-Hee Suh , Brendan Hilliard , Sophia Li , Joan T Merrill , Philip L Cohen Abstract Introduction: The TAM (tyro 3, axl, mer) kinases are key regulators of innate immunity and are important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis. In animal models, absence of TAM kinases is associated with lupus-like disease. To test whether human systemic lupus erythematosus (SLE) patients might have deficient levels of TAM ligands, we measured Gas 6 and protein S levels in SLE. Methods: 107 SLE patients were recruited. Of these, 45 SLE patients were matched age, gender and ethnicity with normal controls (NC). Gas6 and free protein S were measured with sandwich enzyme linked immunosorbent assays (ELISAs). Results: Overall, the plasma concentrations of Gas6 and free protein S were not different between 45 SLE patients and 45 NC. In SLE patients, the levels of free protein S were positively correlated with age (r = 0.2405, P = 0.0126), however those of Gas6 were not. There was no correlation between the concentrations of Gas6 and free protein S in individuals. Levels of free protein S were significantly lower in SLE patients with a history of serositis, neurologic disorder, hematologic disorder and immunologic disorder. Gas6 levels were elevated in patients with a history of neurologic disorder. The SLE patients with anti-Sm or anti-cardiolipin IgG showed lower free protein S levels. Cir
您可能关注的文档
- synthesis and herbicidal activity of substituted pyrazole isothiocyanates合成和除草活性的取代吡唑异硫氰酸酯.pdf
- synthesis and herbicidal activity of 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one esters合成和除草活性的5 -(4-hydroxybenzyl)2-thioxoimidazolidin-4-one酯.pdf
- synthesis and in vitro antimicrobial activity of some pyrazolyl-1-carboxamide derivatives合成和一些pyrazolyl-1-carboxamide衍生物的体外抗菌活性.pdf
- synthesis and in vitro antibacterial activity of 7-(3-amino-6,7-dihydro-2-methyl-2h-pyrazolo[4,3-c] pyridin-5(4h)-yl)fluoroquinolone derivatives7 -合成和体外抗菌活性(3-amino-6,7-dihydro-2-methyl-2h-pyrazolo[4、3 c]pyridin-5(4 h)- yl)氟喹诺酮类衍生品.pdf
- synthesis and in vitro antioxidant activity evaluation of 3-carboxycoumarin derivatives and qsar study of their dpph？ radical scavenging activity合成和体外抗氧化活性评价的定量构效关系研究3-carboxycoumarin衍生品和dpph 自由基清除活性.pdf
- synthesis and in vitro cytotoxic activity of compounds with pro-apoptotic potential合成和体外细胞毒性化合物与pro-apoptotic潜在的活性.pdf
- synthesis and in vitro cytotoxic evaluation of aminoquinones structurally related to marine isoquinolinequinones合成和体外细胞毒性评价海洋isoquinolinequinones aminoquinones结构有关.pdf
- synthesis and in vitro evaluation of new benzothiazole derivatives as schistosomicidal agents合成和体外评价新的苯并噻唑衍生物schistosomicidal代理.pdf
- synthesis and in vitro protein tyrosine kinase inhibitory activity of furan-2-yl(phenyl)methanone derivatives合成和体外蛋白质酪氨酸激酶抑制活性furan-2-yl(苯)methanone衍生品.pdf
- synthesis and insecticidal activities of new ester-derivatives of celangulin-v新酯衍生物的合成及杀虫活动celangulin-v.pdf
- tannin fingerprinting in vegetable tanned leather by solid state nmr spectroscopy and comparison with leathers tanned by other processes单宁植物鞣皮指纹的固态核磁共振光谱和由其他进程与皮革鞣.pdf
- tannins of constant structure in medicinal and food plants—hydrolyzable tannins and polyphenols related to tannins单宁结构常数在医药和食品plants-hydrolyzable单宁和多酚与单宁.pdf
- tailored watershed assessment and integrated management (twaim) a systems thinking approach定制的分水岭评估和综合管理(twaim)系统思考的方法.pdf
- tapered optical fiber sensor for label-free detection of biomolecules锥形光纤传感器label-free生物分子的检测.pdf
- tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis a family-based case–control studytapasin基因多态性在系统性幼年型类风湿性关节炎发作的家族式的病例对照研究.pdf
- tal effectors target the c-terminal domain of rna polymerase ii (ctd) by inhibiting the prolyl-isomerase activity of a ctd-associated cyclophilintal效应器目标c端域的rna聚合酶ii(ctd)通过抑制prolyl-isomerase还有ctd-associated的活动.pdf
- tannins, peptic ulcers and related mechanisms单宁、消化性溃疡及相关机制.pdf
- target dna structure plays a critical role in rag transposition目标dna结构中起关键作用破布换位.pdf
- taqman real-time pcr detects avipoxvirus dna in blood of hawaìi `amakihi (hemignathus virens)taqman实时pcr检测avipoxvirus dna在夏威夷血液amakihi(hemignathus对).pdf
- target drug delivery system as a new scarring modulation after glaucoma filtration surgery目标药物输送系统作为一种新的青光眼滤过手术后疤痕调制.pdf
文档评论（0）