talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report滑石吸入后引起的尘肺病掺假的大麻,案例报告.pdfVIP

Scheel et al. Diagnostic Pathology 2012, 7:26 /content/7/1/26 CASE REPORT Open Access Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report 1,4† 1† 2 3 1* Andreas Hans Scheel , Daniel Krause , Helmut Haars , Inge Schmitz and Klaus Junker Abstract Background: Talcosis, a granulomatous inflammation of the lungs caused by inhalation of talcum dust, is a rare form of pneumoconiosis. Besides inhalative occupational exposure, intravenous abuse of adulterated drugs is a major cause for this condition. Minerals such as talcum (magnesium silicate) and sand (predominant silicon dioxide) are used to increase both volume and weight of illicit substances. In intravenous heroin-abuse, talcosis is a well-known complication. Here we describe a case of talcosis caused by inhalative abuse of adulterated marijuana. Clinical history: A 29-year old man presented with persistent fever, dyspnea and cervical emphysema. He admitted consumption of ‘cut’ marijuana for several years, preferentially by water pipe smoking. Morphologic findings: Lung-biopsies showed chronic interstitial lung disease, anthracotic pigments and birefringent material. Energy dispersive x-ray spectroscopy revealed silicon-containing particles (1-2 μm) and fine aluminum particles ( 1 μm), magnesium and several other elements forming a spectrum compatible with the stated water pipe smoking of talcum-adulterated marijuana. Conclusions: The exacerbated chronic interstitial lung disease in a 29-year old patient could be attributed to his prolonged abuse of talcum-adulterated marjuana by histopathology and x-ray spectroscopy. Since cannabis consumption is widely spread among young adults, it seems to be