synthesis of 2-[4-(4-chlorophenyl)piperazin-1-yl]-2-methylpropanoic acid ethyl ester合成2 -[4 -(4-chlorophenyl)piperazin-1-yl]2-methylpropanoic酸乙酯.pdfVIP

Molbank 2009, M607 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note Synthesis of 2-[4-(4-Chlorophenyl)piperazin-1-yl]-2- methylpropanoic Acid Ethyl Ester Hari N. Pati 1,*, Bijay K. Mishra 1 and Vijay S. Satam 2 1 Department of Chemistry, Sambalpur University, JyotiVihar-768019, Orissa, India 2 Institute of Chemical Technology (ICT), Matunga, Mumbai-400019, Maharashtra, India * Author to whom correspondence should be addressed; E-Mail: hnpati@ Received: 17 May 2009 / Accepted: 30 June 2009 / Published: 27 July 2009 Abstract: The title compound was synthesized by N-alkylation of 4-(4- chlorophenyl)piperazine with ethyl 2-bromo-2-methylpropanoate and its IR, 1H NMR, 13C NMR and Mass spectroscopic data are reported. Keywords: 2-[4-(4-Chlorophenyl)piperazin-1-yl]-2-methylpropionic acid; N-alkylation; 4-(4-Chlorophenyl)piperazine One of the principal interests of our research group is to design and synthesize candidate cytotoxins based on the α,β-unsaturated keto scaffolds [1-3]. A number of these molecules have been shown to alkylate thiols but not amino or hydroxy substituents. Since thiols, in contrast to amino or hydroxyl groups are not found in nucleic acids, α,β-unsaturated ketones are bereft of the carcinogenic and mutagenic properties displayed by various anticancer drugs [4]. A series of compounds, including the title compound 2-[4-(4-chlorophenyl)-piperazin-1-yl]-2-methylpropanoic acid ethyl ester (3) were prepared