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surfactants as microbicides and contraceptive agents a systematic in vitro study表面活性剂作为杀菌剂和避孕剂系统的体外研究
Surfactants as Microbicides and Contraceptive Agents: A Systematic In Vitro Study 1 1. 1. 1 1 Otilia V. Vieira *, Diego O. Hartmann , Carla M. P. Cardoso , Daniel Oberdoerfer , Marta Baptista , 2 1,3 ˜ 1,4,5 6 Manuel A. S. Santos , Luis Almeida , Joao Ramalho-Santos , Winchil L. C. Vaz 1 Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, 2 Department of Biology and CESAM, University of Aveiro, Aveiro, Portugal, 3 Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal, 4 Department of Zoology, University of Coimbra, Coimbra, Portugal, 5 Department of Maternal-Fetal Medicine, Genetics and Human Reproduction, University Hospitals of Coimbra, Coimbra, Portugal, 6 Department of Chemistry, University of Coimbra, Coimbra, Portugal Abstract Background: The urgent need for cheap and easy-to-use protection against both unwanted pregnancies and sexually transmitted diseases has stimulated considerable interest in the use of surfactants as microbicides, anti-viral, and contraceptive agents in recent years. In the present study we report a systematic in vitro evaluation of the microbicidal, anti- viral and contraceptive potential of cationic, anionic, zwitterionic, and non-ionic surfactants. Methodology/Principal Findings: Toxicity was evaluated in mammalian columnar epithelial (MDCK) cells, human sperm cells, Candida albicans, Escherichia coli, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Streptococcus agalactiae and
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