subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution an intervention study亚临床反应健康自行车短暂暴露于空气污染与交通有关的干预研究.pdfVIP

Jacobs et al. Environmental Health 2010, 9:64 /content/9/1/64 RESEARCH Open Access Subclinical responses in healthy cyclists briefly exposed to traffic-related air pollution: an intervention study 1 1,2* 3 3 4 5 Lotte Jacobs , Tim S Nawrot , Bas de Geus , Romain Meeusen , Bart Degraeuwe , Alfred Bernard , Muhammad Sughis1 1 4,6 , Benoit Nemery , Luc Int Panis Abstract Background: Numerous epidemiological studies have demonstrated adverse health effects of a sedentary life style, on the one hand, and of acute and chronic exposure to traffic-related air pollution, on the other. Because physical exercise augments the amount of inhaled pollutants, it is not clear whether cycling to work in a polluted urban environment should be encouraged or not. To address this conundrum we investigated if a bicycle journey along a busy commuting road would induce changes in biomarkers of pulmonary and systematic inflammation in a group of healthy subjects. Methods: 38 volunteers (mean age: 43 ± 8.6 years, 26% women) cycled for about 20 minutes in real traffic near a major bypass road (road test; mean UFP exposure: 28,867 particles per cm3) in Antwerp and in a laboratory with filtered air (clean room; mean UFP exposure: 496 particles per cm3). The exercise intensity (heart rate) and duration of cycling were similar for each volunteer in both experiments. Exhaled nitric oxide (NO), plasma interleukin-6 (IL-6), platelet function, Clara cell protein in serum and blood cell counts were measured before and 30 minutes after exercise. Results: Percentage of blood neutrophils increased significantly more (p = 0.004) after exercise in the road test