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structural elucidation and bioactivity of biflavonoids from the stems of wikstroemia taiwanensis茎的结构说明和生物活性的biflavonoids wikstroemia taiwanensis.pdf

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structural elucidation and bioactivity of biflavonoids from the stems of wikstroemia taiwanensis茎的结构说明和生物活性的biflavonoids wikstroemia taiwanensis

Int. J. Mol. Sci. 2012, 13, 1029-1038; doi:10.3390/ijms130 11029 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Structural Elucidation and Bioactivity of Biflavonoids from the Stems of Wikstroemia taiwanensis Li-Yin Chen 1,*, Ih-Sheng Chen 2 and Chien-Fang Peng 3 1 Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 71710, Taiwan 2 School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mail: m635013@.tw 3 Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; E-Mail: chfape@.tw * Author to whom corresponding should be addressed; E-Mail: eijodesu@.tw; Tel.: +886-6-266-4911 ext. 2209; Fax: +886-6-266-7318. Received: 6 December 2011; in revised form: 1 January 2012 / Accepted: 10 January 2012 / Published: 18 January 2012 Abstract: Three new biflavonoids, wikstaiwanones A–C (1–3), along with four known compounds (4–7) were isolated from the stems of Wikstroemia taiwanensis (Thymelaeaceae). Their structures were elucidated by spectroscopic analysis. Compounds 4 and 5 showed antitubercular activity against Mycobacterium tuberculosis with MIC values of 15 μg/mL, respectively. Keywords: Wikstroemia taiwanensis; Thymelaeaceae; stem; biflavonoid; antitubercular activity 1. Introduction Tuberculos