structural correlates of taste and smell loss in encephalitis disseminata结构关联在脑炎disseminata味觉和嗅觉丧失.pdfVIP

Structural Correlates of Taste and Smell Loss in Encephalitis Disseminata 1,2 1 2 3 3 Felix Alexander Schmidt , Onder Goktas *, Lutz Harms , Georg Bohner , Katharina Erb , Bettina Dahlslett1, Franca Fleiner1 ´ 1 Department of Otolaryngology - Head and Neck Surgery, University of Berlin, Charite Campus Mitte, Smell and Taste Consultation Service, Berlin, Germany, ´ 2 Department of Neurology, Consultation Service for multiple sclerosis, University of Berlin, Charite Campus Mitte, Berlin, Germany, 3 Department of Radiology, University ´ of Berlin, Charite Campus Mitte, Berlin, Germany Abstract Background: Olfactory dysfunction in MS patients is reported in the literature. MRI of the olfactory bulb (OB) is discussed as a promising new testing method for measuring olfactory function (OF). Aim of this study was to explore reasons for and optimize the detection of olfactory dysfunction in MS patients with MRI. Materials and Methods: OB and olfactory brain volume was assessed within 34 MS patients by manual segmentation. Olfactory function was tested using the Threshold-Discrimination-Identification-Test (TDI), gustatory function was tested using Taste Strips (TST). Results: 41% of the MS patients displayed olfactory dysfunction (8% of the control group), 16% displayed gustatory dysfunction (5% of the control group). There was a correlation between the OB volume and the number and volume of MS lesions in the olfactory brain. Olfactory brain volume correlated with the volume of lesions