有哪些信誉好的足球投注网站structural and pharmacological effects of ring-closing metathesis in peptides肽的结构和药理作用的ring-closing置换作用.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
structural and pharmacological effects of ring-closing metathesis in peptides肽的结构和药理作用的ring-closing置换作用
Molecules 2010, 15, 6638-6677; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Structural and Pharmacological Effects of Ring-Closing Metathesis in Peptides Øyvind Jacobsen *, Jo Klaveness and Pål Rongved School of Pharmacy, University of Oslo, Sem Sælands vei 3, P. O. Box 1068 Blindern, 0316 Oslo, Norway; E-Mails: jo.klaveness@farmasi.uio.no (J.K.); pal.rongved@farmasi.uio.no (P.R.) * Author to whom correspondence should be addressed; E-Mail: oyvind.jacobsen@farmasi.uio.no; Tel.: +47 92 81 83 44; Fax: +47 22 85 44 02. Received: 2 June 2010; in revised form: 13 September 2010 / Accepted: 15 September 2010 / Published: 21 September 2010 Abstract: Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β- peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM. Keywords: ring-closing metathesis; peptides; structure; pharmacological properties Table of Contents 1. Introduction 2 2. Synthesis of Peptidic RCM Precursors 4 3. Catalysts, Solvents, Reaction Conditions 5 α α 4. C (i)C (i), m = 4, (Z), n = 5 cyclizations 6 α α 5. C (i)C (i+1), m = 4, (Z)/H , n = 8 cyclizations 6 2 6. Cα(i)N(i+1), m = 4-6, (Z), n = 7-9 cyclizations 7 7. Cα(i)CO(i+1), m = 10, H , n = 15 cyclizations 8 2 8. Cα α
您可能关注的文档
- specific alterations in complement protein activity of little brown myotis (myotis lucifugus) hibernating in white-nose syndrome affected sites具体修改补充蛋白质的活性小棕鼠耳蝠(鼠耳蝠lucifugus)冬眠在白鼻综合症影响网站.pdf
- specific and sensitive detection of h. pylori in biological specimens by real-time rt-pcr and in situ hybridization特异、敏感检测幽门螺杆菌在生物标本的实时rt - pcr和原位杂交.pdf
- species-specific activity of hiv-1 vpu and positive selection of tetherin transmembrane domain variants导致的hiv - 1的活性vpu和积极的选择tetherin跨膜域变异.pdf
- specific capture and whole-genome sequencing of viruses from clinical samples具体从临床样本捕获和病毒的全基因组测序.pdf
- spatial variations in the incidence of breast cancer and potential risks associated with soil dioxin contamination in midland, saginaw, and bay counties, michigan, usa空间乳腺癌的发病率的变化和潜在的风险与土壤中二恶英污染的米德兰,和海湾县,美国密歇根州萨吉诺.pdf
- species-specific fungal dna in airborne dust as surrogate for occupational mycotoxin exposure种特异的真菌dna在空中尘埃作为职业霉菌毒素风险代理.pdf
- specific cytogenetic labeling of bovine spermatozoa bearing x or y chromosomes using fluorescent in situ hybridization (fish)特定的细胞遗传学标记的牛精子轴承使用荧光x或y染色体原位杂交(鱼).pdf
- specific binding of anionic porphyrin and phthalocyanine to the g-quadruplex with a variety of in vitro and in vivo applications特定绑定的阴离子卟啉和酞菁g-quadruplex各种体外和体内应用.pdf
- specific expression of channelrhodopsin-2 in single neurons of caenorhabditis elegans具体表达单一神经元的名为u201c线虫.pdf
- specific eradication of hiv-1 from infected cultured cells根除特定的hiv - 1感染培养的细胞.pdf
- structural and molecular characterization of meso-substituted zinc porphyrins a dft supported study结构和分子特征meso-substituted锌卟啉dft支持研究.pdf
- structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the abl tyrosine kinase domain激酶抑制剂的结构和光谱分析bosutinib和异构体bosutinib绑定abl酪氨酸激酶域.pdf
- strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma a case report类圆线虫属stercoralis高度传染的风湿性关节炎患者,支气管哮喘病例报告.pdf
- structural and functional loss in restored wetland ecosystems在恢复湿地生态系统结构和功能损失.pdf
- structural and transcriptional analysis of plant genes encoding the bifunctional lysine ketoglutarate reductase saccharopine dehydrogenase enzyme植物基因编码的结构和转录分析双官能赖氨酸酮戊二酸盐还原酶saccharopine脱氢酶酶.pdf
- structural and functional insights into endoglin ligand recognition and binding结构和功能的见解endoglin配体识别和绑定.pdf
- structural antitumoral activity relationships of synthetic chalcones合成化合物的结构antitumoral活动关系.pdf
- structural basis for dual-inhibition mechanism of a non-classical kazal-type serine protease inhibitor from horseshoe crab in complex with subtilisin结构性基础dual-inhibition机制的非经典的kazal-type丝氨酸蛋白酶抑制剂与枯草杆菌蛋白酶从复杂的马蹄蟹.pdf
- structural basis of ets1 cooperative binding to widely separated sites on promoter dnaets1合作基础结构绑定到广泛的网站启动子dna分离.pdf
- structural basis for specificity of propeptide-enzyme interaction in barley c1a cysteine peptidases特异性结构依据propeptide-enzyme交互的大麦c1a半胱氨酸肽酶.pdf
文档评论（0）