statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke他汀类药物预处理降低血小板活性和良好的结果在急性non-cardio-embolic缺血性中风患者.pdfVIP

Tsai et al. Critical Care 2011, 15:R163 /content/15/4/R163 RESEARCH Open Access Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke 1 1 1 2 1 1 Nai-Wen Tsai , Tsu-Kung Lin , Wen-Neng Chang , Chung-Ren Jan , Chi-Ren Huang , Shang-Der Chen , 3 4 5 5 5 6 Kuei-Yueh Cheng , Yi-Fang Chiang , Hung-Chen Wang , Tzu-Ming Yang , Yu-Jun Lin , Wei-Che Lin , Hsueh-Wen Chang7, Lian-Hui Lee1* and Cheng-Hsien Lu1,7* Abstract Introduction: Statins reportedly have anti-inflammatory and anti-thrombotic effects aside from cholesterol- lowering. This study aimed to evaluate the effect of pre-existing statin use on platelet activation markers and clinical outcome in acute ischemic stroke patients. Methods: This prospective study evaluated 172 patients with acute ischemic stroke divided in two groups: patients with pre-existing statin (n = 43) and without pre-existing statin (66 cases with statins initiated post-stroke and 63 without statin treatment). Platelet activation markers (CD62P and CD63) were measured by flow cytometry at different time points after stroke and analyzed with clinical outcome. Results: The CD62P and CD63 expressions on platelets were significantly lower in the patients with pre-existing statin use compared to the patients without pre-existing statin use on Day 1 post-stroke (p 0.05). The CD62P expression was significantly lower in the patients with pre-existing statin use on 90 days after the acute stroke (p 0.05). Patients with pre-existing statin use had lower incidences of early neurologic d