specific receptor usage in plasmodium falciparum cytoadherence is associated with disease outcome使用特定的受体在恶性疟原虫cytoadherence与疾病相关联的结果.pdfVIP
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specific receptor usage in plasmodium falciparum cytoadherence is associated with disease outcome使用特定的受体在恶性疟原虫cytoadherence与疾病相关联的结果
Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome 1 1 1 3 1 Lucy B. Ochola *, Bethsheba R. Siddondo , Harold Ocholla , Siana Nkya , Eva N. Kimani , Thomas N. 1,6 1 4 1,2 1,5 2 Williams , Johnstone O. Makale , Anne Liljander , Britta C. Urban , Pete C. Bull , Tadge Szestak , Kevin Marsh1,5, Alister G. Craig2 1 KEMRI/Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya, 2 Department of Molecular Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, 3 Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania, 4 Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden, 5 Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom, 6 Department of Paediatrics, University of Oxford, Oxford, United Kingdom Abstract Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence pa
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