有哪些信誉好的足球投注网站specific protein kinase c isoforms α and βi are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption特定的蛋白激酶c亚型α和βi参与促卵泡病时鼠标follicle-enclosed卵母细胞减数分裂恢复.pdfVIP
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specific protein kinase c isoforms α and βi are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption特定的蛋白激酶c亚型α和βi参与促卵泡病时鼠标follicle-enclosed卵母细胞减数分裂恢复
Specific Protein Kinase C Isoforms a And bI Are Involved in Follicle-Stimulating Hormone-Induced Mouse Follicle- Enclosed Oocytes Meiotic Resumption 1. 1. 2 1 1 1 1 1 Jianwei Wang , Qian Chen , Jinlian Zhou , Jing Wen , Fenghua Bian , Ge Li , Xinyi Mu , Yingying Han , 1 1 Guoliang Xia , Meijia Zhang * 1 State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, People’s Republic of China, 2 Department of Pathology, 306 Hospital of PLA, Beijing, People’s Republic of China Abstract Protein kinase C (PKC) is involved in gonadotrophin-induced oocyte maturation. In the present study, we investigated the role of specific PKC isoforms in the process of follicle-stimulating hormone (FSH)-induced oocyte meiotic resumption. Small antral follicles (200–300 mm in diameter) were isolated from immature mice and cultured in vitro. FSH significantly induced follicle-enclosed oocytes (FEOs) meiotic resumption after 8 hr culture. However, the induced effect of FSH was dose- ¨ ¨ dependently inhibited by the specific PKC a and bI inhibitor Go6976, and 100 nM Go6976 completely blocked FSH function in oocyte meiotic resumption. Furthermore, FSH dramatically induced the expression of transcripts encoding epidermal growth factor (EGF)-like growth factors Areg, Btc, and Ereg mRNA levels, and up-regulated tyrosine phosphorylation level of EGF receptor (EGFR) in granulosa cells. Blocking the function of EGFR by AG1478 eliminated the effect of FSH-induced FEOs meiotic resumption, suggesting that FSH induced o
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